Clinical Research

Tennessee Comprehensive Lung and Sleep Center offers a gateway to the frontiers of research and development in the field of pulmonary medicine. Pharmaceutical companies ask our physicians to serve as primary investigators for their studies in the development of treatments for diseases like asthma and COPD. Within the framework of our center, we have a research team that allows us to screen patients for immediate consideration in new and innovative therapeutic studies. If you are interested in participating in one of our research studies, please contact our clinical research department.

Dr. Clyde Southwell, MD, FCCP.
Email: or Phone: (615) 822-2214

Wanda Smith, CRC
Email:  or Phone (615) 431-0469

Wanda Smith, Clinical Research Coordinator

Clinical Research Professional with 17 years of experience responsible for running the day to day aspects of clinical trials. Primary concern is caring for the patients, protecting them , and delivering excellence to our Pharma partners.

Research responsibilities include:

  • Facilitating complex clinical trials, monitoring data, meeting data endpoints, creating tools for sufficient delivery.
  • Recruiting subjects, consenting potential subjects, explaining the trials simply and answering questions.  Checking in on the subjects to monitor compliance.
  • Responsible for building, managing and developing Sponsor relationships at strategic levels.
  • Adherence to the set guidelines of the International Conference on Harmonization to ensure the clinical trial is carried on using Good Clinical Practice and according to the laws on how clinical trials are to be conducted.

Mrs. Smith is married.  She enjoys spending time with her family, exploring the great outdoors and reading.   She believes everyone should be treated with kindness and compassion.

Currently Enrolling Clinical Trials at TCLS:
Resolute (COPD):

A Phase 3 Study for Patients With Moderate To Very Severe Chronic Obstructive Pulmonary Disease (COPD) With A History Of Frequent COPD Exacerbations And Elevated Peripheral Blood Eosinophils

Fibrogen (IPF):

A Phase 3. Randomized double blind study for subjects with Idiopathic Pulmonary Fibrosis

Regeneron (Asthma):

Randomized double blind study to evaluate the effect of the drug on exercise capacity in patients with moderate to severe asthma.

Chronicle (Asthma):

Observational study of the characteristics, treatment patterns and health outcomes of individuals with severe asthma in the United States.


Evaluation of HFCWO using the Vest System for Treatment of Non-Cystic Fibrosis Bronchiectasis in the home setting.